Preheat oven to 450 degrees or 425 convection
In a medium-sized mixing bowl, add the flour, hot sauce, garlic powder, and garlic powder. Slowly mix in water (1/4 cup at a time) until you reach the consistency of pancake batter.
In batches (about 6-10 florets at a time), mix the florets in the batter until the are fully coated. Remove each piece, one at a time, tapping it on the side of the bowl to allow excess batter to drip back into the bowl. Place pieces on parchment paper-lined or silicone mat-lined baking sheet (with sides).
Sprinkle Panko breadcrumbs carefully over the tops of each coated floret.
Bake for 20-30 minutes, watching them closely to make sure they're not burning. You want them crispy but not burned. If need be, reduce the heat to 400 degrees if you feel like they are getting too brown too fast. After 20 minutes, insert a fork in one of the largest florets to see if it's just tender in the center. If not, let it bake another 5 minutes and check again. They shouldn't take more than 30 minutes to be done.
Serve with ranch dressing!